NEW STEP BY STEP MAP FOR METHADONE ADVERSE EFFECTS

[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that's a lot less potent being an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone features a lower affinity, with an IC50 o